Twin-to-twin transfusion syndrome (TTTS), also known as
It can affect monochorionic multiples, that is, multiple pregnancies where two or more fetuses share a chorion and hence a single placenta.
Twin to Twin Transfusion Syndrome is a very serious complication affecting approximately 15% of identical twin pregnancies.
Monochorionic vs TTTS Twins
source: Ritesh Mahajan, Radiologist at Mercury Imaging Centre Chandigarh
Twin-to-Twin Transfusion Syndrome
Twin-to-Twin Transfusion Syndrome (TTTS) is a disease of the placenta. It affects only monozygotic (“identical”) twins sharing a single placenta. As the placenta develops, the blood vessels form in such a way that vessels from one umbilical cord connect up with vessels from the other. This causes a sort of “short circuit” between the babies. It can create a transfusion situation where one baby does not have an opportunity to process fluid coming to it because the fluid immediately gets sent over to the second baby.
- Recipient: The baby that is receiving the extra blood from the placenta, due to the transfusion syndrome
- Donor: The baby that is receiving less blood as a result of the transfusion syndrome
- Stuck Twin: The donor twin will appear stuck to the wall of the chorionic sac on an U/S. This is because there is little or no amniotic fluid inside the baby’s amniotic sac and the dividing membrane has shrink wrapped to the wall. The membrane separating the twins can be difficult or impossible to find when the donor baby is completely stuck to the wall of the sac.
- Hydrops: Water droplets that form in the recipient baby’s body tissue as a result of organs being overworked
- Amniocentesis: The procedure employed for the periodic draining of amniotic fluid from the sac of the recipient in order to balance the pressure between the babies
- Septostomy: The intentional rupturing of the dividing membrane between the babies; this creates a Monoamniotic pregnancy (see Monoamniotic below).
- Fused Placenta: When the placentas of fraternal twins form close together in the womb, it is possible for them to grow into each other. On an ultrasound, they are almost indistinguishable from a single placenta. Even post-birth biopsy can not always enable doctors to distinguish a single placenta from a fused placenta.
- Monoamniotic (MoMo): Some identical twins share both the chorionic sac and the amniotic sac. This is an uncommon configuration for identical twins and has many risks associated with it. TTTS patients are sometimes misdiagnosed as Monoamniotic since in both cases there is no visible dividing membrane (see Stuck Twin above).
Stages of Twin-to-Twin Syndrome
- Stage I TTTS: Less then 2 cm of amniotic fluid around the donor and greater then 8 cm of amniotic fluid around the recipient
- Stage II TTTS: Same as Stage I without any visible bladder in the donor baby.
- Stage III TTTS: Same as Stage I (atypical) or Stage II (classic) with critically abnormal Doppler readings.
- Stage IV TTTS: Same as Stage III with visible hydrops
- Stage V TTTS: One or both babies have died
How is TTTS Identified?
Often, the first sign of TTTS is a “stuck” twin. This is caused by one baby not receiving enough placental blood to make much, if any, amniotic fluid. The membrane separating the babies will shrink wrap the baby to the side of the amniotic sac. Doppler ultrasound can also detect uneven or unbalanced flow within the two cords. Other signs are a weight and/or size differential of 10%-20% between the twins. Often, the mother’s belly can grow so quickly that it could measure 24 weeks one day and 40 weeks 4 days later.
- Same sex babies (must)
- Single placenta (not fused)
- Size discordance (typically >15%)
- Amniotic fluid measurement difference: less than 1 cm around donor; greater than 10 cm around recipient
- Significant difference in cord Doppler readings
- Hydrops in recipient (water forming in body tissue)
- larger then normal uterus for gestational age of twins
- one baby is felt kicking while the other is not
When Does Twin-to-Twin Syndrome Happen?
TTTS can strike at any time during the pregnancy. Usually, a first trimester occurrence of chronic TTTS is fatal and there is nothing mother or medicine can do about it. No one has proven it yet, but it is suggested and stands to reason that there are probably lots of parents who never know that there were twins growing in there before the babies pass on and begin to be absorbed back into the womb.
Second trimester chronic TTTS is very problematic because any invasion of the womb could trigger pre-term labor, which would be fatal at this point. The babies are too small to deliver and too big for re-absorption. Current procedures give these twins a fighting chance where, even just a few years ago, little chance existed.
Third trimester chronic TTTS is perhaps the easiest to deal with. In this case, the babies are viable outside the womb, so, if things get too bad, the option to deliver is real.
TTTS Frequently Asked Questions
In this Video Dr. Ahmet Baschat, Director of the Johns Hopkins center for Fetal Therapy answers the most common questions about Twin to Twin Syndrome.
- How common is TTTS?
- When is a mother typically diagnosed with TTTS?
- What happens if it goes untreated?
- How is twin-to-twin transfusion syndrome typically treated?
- What are the risks of this procedure?
- What can a patient expect after this procedure?
- Is there any special follow up required after the birth of the twins?
Twin-to-Twin Transfusion Syndrome Treatment Options
Septostomy (also known as microseptostomy)
Selective laser ablation of the placental anastomotic vessels
Selective cord coagulation
There's Always Hope
A diagnosis of TTTS is a shock to parents who have been joyfully expecting an uneventful pregnancy. Like many medical mysteries, the cause and development of TTTS is not yet fully understood by even the leading doctors in the field of TTTS research, but more and more is being learned every day. Huge advances in the ability to analyze and diagnose TTTS have been made over the past couple of years.
New laser techniques pioneered by Dr. Quintero (Tampa) and Dr. De Lia (Milwaukee) are showing amazing success when compared to more traditional methods of combating the disease and there are several programs around North America and Europe that are currently working hard to understand the syndrome better so that a better treatment plan can be.prescribed.
Unfortunately, most doctors practicing today were trained before these advances were known, and the currently available statistics on TTTS do not reflect the most recent successes, either. As a result, few doctors are actually current on the newest techniques for diagnosing and treating the disorder, and this results in some less than accurate assessments of the babies’ chances of survival.
Until the general medical community is familiar with the advances in the field, and the literature reflects the newer, more positive statistics, patients may need to, advocate for themselves and their babies and look a little harder to find the right course of action for them. There are new procedures and protocols available today to improve your babies chances of surviving TTTS.
What Can You Expect
First of all, I want to stress that because of different combinations of cross-connecting and different sizes of those vessels that do cross-connect, this disease can show up in a very wide number of ways. As there is little that can be done in the early stages of the pregnancy, I will try to focus more on second and third trimester cases.
It is not uncommon for a TTTS pregnancy to be mistaken for Monoamniotic (MoMo) early on, if the donor baby is not receiving excess blood right from the beginning. The diagnostic clue is that the donor baby will be “stuck” to the wall of the womb and will move its limbs little, if at all, during the ultrasound reading. It may also be difficult to detect the donor baby’s bladder through ultrasound, if TTTS has progressed far enough.
Each ultrasound visit should include a Doppler reading of the blood flow in the cords and other places. In the cords, differences in flow should be measured and noted and, if possible, the number of vessels that are functioning in each cord should be determined. This can give you an idea about placenta share and it can be a supporting clue in a TTTS diagnosis.
If TTTS is allowed to progress without intervention, the recipient baby may begin to experience a hardening of the heart. This is caused by 2 factors: 1) the amount of blood being processed (since this baby is getting its own supply plus some of its sibling’s) and 2) the thickness of the blood. This hardening of the heart can progress to a point where heart failure occurs.
Should heart failure begin, water drops, called hydrops, will form in the recipient’s body tissue. This will usually precede the demise of the baby by only a couple of days, if that many. However, should TTTS be corrected by any method, (such as amniotic fluid reductions, surgery or birth) before it has advanced to far into this stage, the heart will usually correct itself as it grows.
Anemia is the biggest problem for the donor. If left untreated, TTTS-driven anemia will be terminal for the donor baby. Again, if intervention corrects the transfusion syndrome, then the anemia will correct itself.
What Can You Do Now?
The first thing you should do upon receiving a TTTS diagnosis is find out the answers to the following questions, if possible:
- What is the gestational age of the babies?
- Are they same gender? (Even if you do not want to know the babies’ genders, you NEED to know if they are the same, whatever they are)
- Is there a single, shared placenta? (Ask if there is any previous evidence of there having been two placentas; this may help identify a fused placenta)
- What is the size difference between the babies?
- What is the fluid level around each baby?
- Are hydrops present?
The second thing you should do is schedule a second opinion. This is no reflection on your doctor’s abilities. Twins occur about once in every sixty pregnancies. Monozygotic twins account for about
Since doctors do not see it often, they may not feel compelled to spend much time keeping up to date with it. It is always my recommendation to get a second opinion from one of the leading experts in the TTTS field. One good thing about the second opinion here is that it does not require a second trip to the doctor. Doctors can review the U/S results remotely. You need only get in touch with the two doctors’ offices and they will transfer the information. In many cases, contacting one or the other is enough, as long as you supply all of the necessary contact information.
TTTS progresses rapidly once it begins showing its ugly head. Often, the prognosis is grim. Due to the low occurrence of TTTS in the population, and the newness of some of the treatment plans, it could be a number of years before the statistics available to most doctors accurately reflect the growing success rate of the new medical procedures. Most doctors currently believe that, when left untreated, chronic TTTS diagnosed before week 25 is so close to 100% fatal that survival odds are almost negligible.
You may be told that you have, at best, a 5-10% chance of taking even one baby home some day. Most parents are devastated. When parents finds out that a child is on the way, they begin preparing emotionally and logistically. When they find out there are 2 babies on the way, they often go into overdrive and double their commitment to the pregnancy. It is difficult enough to come to terms with the fact that it is twins; to deal with the prospect of the imminent loss of both can be devastating.
The third thing you should do is find hope. Seek out someone who has traveled the road of TTTS. I cannot encourage you strongly enough to get in touch with someone who has walked this road ahead of you.. Thanks to the various new techniques, TTTS patients enjoy a tremendous and rising success rate, and talking about this with someone who has experienced it, and hearing their success story, can be tremendously reassuring and empowering. Today, with proper treatment, there is a lot of reason for hope.
TTTS Survivor Stories
Forever Linked: A Mother's Journey Through Twin to Twin Transfusion Synrome
In this book Erin Bruch shares the powerful and heart wrenching story of how her most blessed event became her greatest trial when her unborn twins were diagnosed with TTTS. She shares her personal reflections, the nature of this disease, current treatments, and the practical and emotional advice for families facing the diagnosis.
Twin-to-Twin Transfusion Syndrome - 1st Edition
This concise guide describes the etiology, diagnosis and treatment of TTTS. Divided into six sections, the book begins with the history of the condition, then the basics, clinical features and diagnosis, to the most recent advances in its management and related ethical issues
Resources for Help and More Information:
The only non profit organization in the USA dedicated solely to TTTS. Provides support by e-mail and phone. Provides a comprehensive book on TTTS to newly diagnosed TTTS patients via the mail. Provides other support on a case by case basis. Some information regarding TTTS.
Fetal Health Foundation
A 501(c)(3) non-profit charity that provides factual medical information on fetal syndromes, provides unconditional support to families dealing with these syndromes, provides advocacy and awareness around fetal syndromes and provides research grants funding new treatments and technologies.